Labels:text | font | screenshot | black and white OCR: As illustrated, the sickle-cell mutation changes a single amino acid in one of the two types of globin polypeptides that make up hemoglobin. This change in just one amino acid alters the structure of hemoglobin, which causes red blood cells to have an abnormal sickled shape. The severe manifestations of the disease at the organismal level are caused both by the destruction of the sickle cells and by their clumping and accumulation in various tissues and organs. Sickle-cell anemia exemplifies the complex cascade of events that is often interposed between an organism's ultimate phenotype and the genotype it inherited.
